Hillenmeyer ME~Giaever G, 2008

Pubmed ID	18420932
Title	The chemical genomic portrait of yeast: uncovering a phenotype for all genes.
Authors	Maureen E Hillenmeyer, Eula Fung, Jan Wildenhain, Sarah E Pierce, Shawn Hoon, William Lee, Michael Proctor, Robert P St Onge, Mike Tyers, Daphne Koller, Russ B Altman, Ronald W Davis, Corey Nislow, Guri Giaever
Abstract	Genetics aims to understand the relation between genotype and phenotype. However, because complete deletion of most yeast genes ( approximately 80%) has no obvious phenotypic consequence in rich medium, it is difficult to study their functions. To uncover phenotypes for this nonessential fraction of the genome, we performed 1144 chemical genomic assays on the yeast whole-genome heterozygous and homozygous deletion collections and quantified the growth fitness of each deletion strain in the presence of chemical or environmental stress conditions. We found that 97% of gene deletions exhibited a measurable growth phenotype, suggesting that nearly all genes are essential for optimal growth in at least one condition.
Citation	Science 2008; 320:362-5

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	Paper	Phenotype	Condition	Medium	Collection	Tested mutants	Data	Details
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	1,3-Diallylurea [20 mM], time [o/n + 20 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	1,3-Diallylurea [10 mM], time [o/n + 20 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	1,4-Dimethylendothall [100 uM], time [o/n + 20 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	1,2:7,8-diepoxyoctane [0.25%], time [o/n + 20 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	1,8-Nonadiene [0.49%], time [o/n + 20 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	1,8-Nonadiene [0.99%], time [o/n + 20 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	2-CYANOETHYL ACRYLATE [360 mM], time [5 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	temperature [23ºC], time [o/n + 5 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	temperature [23ºC], time [o/n + 15 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	temperature [25ºC], time [o/n + 5 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	temperature [25ºC], time [o/n + 15 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	temperature [37ºC], time [o/n + 5 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	temperature [37ºC], time [o/n + 20 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	4-nitroquinoline N-oxide [0.0313 uM], time [5 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	5-fluorouracil [9.6 uM], time [o/n + 20 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	5-fluorouracil [19.1 uM], time [o/n + 20 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	5-fluorouracil [19.2 uM], time [o/n + 5 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	5-fluorouracil [19.2 uM], time [o/n + 15 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	5-fluorouracil [38.46 uM], time [o/n + 5 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	5-fluorouracil [38.46 uM], time [o/n + 15 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	5-fluorouracil [38.46 uM], time [o/n + 20 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	5-fluorouracil [250 uM], time [o/n + 20 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	acetic acid [50 uM], time [o/n + 20 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	aclacinomycin A [32.25 uM], time [o/n + 20 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	acriflavinium chloride [250 uM], time [o/n + 20 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	time [o/n + 5 gen]	SC - Ade	hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	Adenophostin A [500 uM], time [o/n + 20 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	MLS002701581 [500 uM], time [o/n + 20 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	aclacinomycin T hydrochloride [250 uM], time [o/n + 20 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	alizarin [66 uM], time [o/n + 20 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	diallyl disulfide [0.01%], time [o/n + 20 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	diallyl disulfide [0.016%], time [o/n + 20 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	diallyl disulfide [0.06%], time [o/n + 20 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	Diallyl sulfide [0.12%], time [o/n + 20 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	alverine citrate [500 uM], time [o/n + 20 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	amphotericin B [0.31 uM], time [o/n + 20 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	amsacrine [500 uM], time [o/n + 20 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	angelicin [62.5 uM], time [5 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	angelicin irradiated		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	time [o/n + 5 gen]	SC - Arg	hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	aureobasidin A [0.02 ug/ml], time [5 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	4,7-diphenyl-1,10-phenanthroline 4',4''-disulfonate [75 uM], time [o/n + 20 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	4,7-diphenyl-1,10-phenanthroline 4',4''-disulfonate [100 uM], time [o/n + 20 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	carmustine [62.5 uM], time [o/n + 20 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	BCS [100 uM], time [o/n + 20 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	BCS [200 uM], time [o/n + 20 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	benomyl [10 ug/ml], time [5 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	benomyl [10 ug/ml], time [o/n + 5 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	benzaldehyde [0.003%], time [5 gen]		hom	4,742	Quantitative
	Hillenmeyer ME~Giaever G, 2008	growth (pooled culture)	Berberine chloride (TN) [125 uM], time [o/n + 20 gen]		hom	4,742	Quantitative

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Curation history

Tested strains
May 3, 2016	Ready to load.
May 11, 2016	Loaded.

Data
May 3, 2016	Ready to load.
May 11, 2016	Loaded.